Teratogenic action of platinum thymine blue.

Trypan blue induced teratogenesis of rat embryos cultivated in vitro.

Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...

The failure of glutamic acid to protect the rat embryo against the action of trypan blue.

The effect of L-glutamic acid on the embryolethal and teratogenic action of trypan blue was investigated in Wistar albino rats. L-glutamic acid was either incorporated into the diet, from gestation day 2 to day 20, or suspended in sesame oil and administered by gavage, from gestation day 6 to day 10. The day of finding sperm in the vaginal smear was designated day 0 of pregnancy. A teratogenic ...

Teratogenic action of the thyroid stimulating hormone and its interaction with trypan blue.

The relationship of chemical structure to teratogenic activity among bisazo dyes: a re-evaluation.

Although the potency of trypan blue as a teratogenic agent in rodents has been known for almost twenty years the mechanism of its action remains obscure. The dye produces a variety of biological effects (see review by Beck & Lloyd, 1966) and most of these have at some time been suggested as possibly relevant to its teratogenicity. The investigation of such correlations would clearly be assisted...

Teratogenic effects of trypan blue on hamster embryos.

L I T T L E information is available in the literature on the susceptibility of the hamster embryo to teratogens. Desoxycorticosterone acetate apparently has some teratogenic activity (Tedford & Risely, 1950), but the degree and type of abnormality produced by this agent in the hamster have not been recorded. Orsini (1952) has described naturally-occurring urogenital anomalies which appear in f...